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T3086 |
Mesoridazine Besylate
|
Mesoridazine benzenesulfonate,Serentil |
Dopamine Receptor
,
5-HT Receptor
|
|
Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine. |
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T4274 |
Melitracen hydrochloride
|
Thymeol hydrochloride,Melixeran |
Dopamine Receptor
,
5-HT Receptor
|
|
Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression. |
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T1327 |
Nortriptyline hydrochloride
|
Desitriptyline HCl,EN-7048 hydrochloride,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride |
Apoptosis
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Autophagy
,
Histamine Receptor
,
Drug Metabolite
|
|
Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. |
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T37015 |
Iprindole
|
|
5-HT Receptor
|
|
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. |
|
T22240 |
Amitriptyline
|
|
Sigma receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
|
T0172 |
Maprotiline hydrochloride
|
Maprotiline HCl,Psymion,Deprilept,Ludiomil |
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Autophagy
,
Histamine Receptor
|
|
Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use. |
|
T12232 |
Nitroxazepine
|
CIBA 2330Go |
Serotonin Transporter
|
|
Nitroxazepine (CIBA 2330Go) is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
|
T7941 |
Imipramine hydrochloride
|
Imipramine (hydrochloride),Tofranil,G 22355,Imipramine HCl,Melipramine |
Serotonin Transporter
|
|
Imipramine hydrochloride (Imipramine HCl) is a first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively).Imipramine hyd... |
|
T1568 |
Amoxapine
|
CL-67772 |
GlyT
|
|
Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopa... |
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T60330 |
Metapramine
|
|
|
|
Metapramine (19560 RP) is a tricyclic antidepressant[1]. Metapramine inhibits norepinephrine reuptake without affecting the reuptake of serotonin or dopamine [1] [2] [3]. Metapramine is a low-affinity antagonist of the N... |
|
T0204 |
Protriptyline hydrochloride
|
Protriptyline HCl |
5-HT Receptor
,
AChE
|
|
Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline, a tricyclic secondary amine with an antidepressant property. Protriptyline hydrochloride (Protriptyline HCl) blocks the re-uptake of norepineph... |
|
T0678 |
Amitriptyline hydrochloride
|
Amitriptyline HCl,Tryptizol,Domical,Annoyltin |
Trk receptor
,
Sigma receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
|
T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
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T15773 |
Lofepramine
|
Gamanil,Amplit,Leo 640,Lopramine |
5-HT Receptor
,
Norepinephrine
|
|
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, ... |
|
T0991 |
Desipramine hydrochloride
|
NSC-114901,Desmethylimipramine,JB-8181,EX-4355,Norimipramine,G-35020 |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Adrenergic Receptor
|
|
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-upt... |
|
T68070 |
Fezolamine
|
|
Norepinephrine
|
|
Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytrypta... |
|
T20017 |
Melitracen
|
Melitracene |
|
|
Melitracen is a tricyclic antidepressant. |
|
T25248 |
Cianopramine
|
Ro 112465,Ro-112465,Ro112465 |
|
|
Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals. |
|
T15132L |
Dimetacrine tartrate
|
Linostil,Istonil,Istonyl,Miroistonil,MO 709 |
|
|
Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan. |
|
T13377 |
(Z)-10-Hydroxynortriptyline
|
(Z)-10-Hydroxy Nortriptyline |
IL Receptor
|
|
(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression. |
|
T37307 |
Nordoxepin hydrochloride
|
|
|
|
Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety ... |
|
T69620 |
Demexiptiline
|
|
|
|
Demexiptiline is a tricyclic antidepressant used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine. |
|
T82804 |
Butriptyline
|
Butriptylene |
|
|
Butriptyline (Butriptylene), a tricyclic antidepressant, is effective when administered orally [1]. |
|
T11135 |
(E)-10-Hydroxynortriptyline maleate
|
(E)-10-Hydroxy Nortriptyline maleate |
Others
|
|
(E)-10-Hydroxy Nortriptyline maleate, a metabolite of Nortriptyline, serves as a key active metabolite of the tricyclic antidepressant Amitriptyline, primarily utilized in alleviating depression symptoms. |
|
T71773 |
Levomepromazine Maleate
|
|
|
|
Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anti... |
|
T74205 |
Imipramine N-oxide
|
|
|
|
Imipramine N-oxide, a metabolite of Imipramine, is a tertiary amine tricyclic antidepressant [1] [2]. |
|
T69579 |
Dothiepin HCl
|
|
|
|
Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergi... |
|
T11008 |
Desmethylnortriptyline
|
|
Others
|
|
Desmethylnortriptyline is a metabolite of nortriptyline. Nortriptyline is a tricyclic antidepressant. It is the main active metabolite of amitriptyline and is used to relieve depressive symptoms. |
|
T61741 |
Azaphen dihydrochloride monohydrate
|
|
|
|
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIs Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment ofdepression. In addition to... |
|
T38131 |
(E)-10-Hydroxynortriptyline
|
|
|
|
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1... |
|
T61376 |
Opipramol
|
|
|
|
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed i... |
|
T78564 |
Depramine
|
GP 31406 |
|
|
Depramine (GP 31406), a tricyclic antidepressant, exhibits pharmacological activity by inhibiting acetylcholinesterase, Mg^2+-ATPase, and Na^+/K^+ ATPase activity [1] [2]. |
|
T11088 |
Doxepin D3 Hydrochloride
|
|
Histamine Receptor
|
|
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepin hydrochloride is also an effective CYP450 inhibitor, signi... |
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T69943 |
Citalopram oxalate
|
|
|
|
Citalopram oxalate is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients wh... |
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T71537 |
Tofenacin hydrochloride
|
|
|
|
Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinerg... |
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T70487 |
Tofenacin (free base)
|
|
|
|
Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic... |
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T60445 |
Desipramine
|
|
|
|
Desipramine is a tricyclic psychotic compound with antidepressant activity. Desipramine inhibits the norepinephrine reuptake receptor in the central nervous system and reduces the sleep-related loss of genioglossus activ... |
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T60521 |
Doxepin
|
|
|
|
As a tricyclic antidepressant, Doxepin inhibits the reuptake of serotonin and norepinephrine. Doxepin shows therapeutic effects on atopic dermatitis and chronic urticaria that also improves cognitive processes as well as... |
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T74582 |
Trimipramine N-oxide
|
|
|
|
Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organ... |
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T70960 |
Maprotiline-d3 hydrochloride
|
|
|
|
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selecti... |
